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Table 3 summarizes key nanoplatforms used in drug delivery, highlighting their advantages and limitations

A recent study has shown that Yap is associated with the activation of ferroptosis, Yap can promote an iron environment in cancer cells through stimulating transcription of TEAF-based members of the Transferrin receptor (TFRC) and Acyl-CoA synthetase long chain family 4 (ACSL4) [129, 130]

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Moreover, DHA-enriched diets alleviate NAFLD-associated characteristics and ferroptosis-induced hepatic injury in zebrafish

In addition to direct effects on hepatic lipid synthesis, LXR repression exerts pleiotropic effects to reduce dyslipidemia

However, HDAC6 inhibitors are poorly soluble in water which restricts their bioavailability and BBB permeability