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Most certainly, the sinus ligated to the bone ascertained definitive occlusion, skull bone overlying the sinus eliminated the risk of sinus tear

Yesiladali M, Yazici MGK, Attar E, Kelestimur F

Whilst leg cramps are not formally listed as a recognised adverse effect in UK product information, patients occasionally report muscle cramping during treatment

Effect of lipid peroxidation on the properties of lipid bilayers: a molecular dynamics study

Atayde VD, Jasiulionis MG, Cortez M, Yoshida N

As a catalytic cofactor, zinc is involved in all six enzyme classes (oxidoreductases, transferases, hydrolases, lyases, isomerases, and ligases), either directly driving bond-making and bond-breaking reactions at the active site (catalytic zinc) or enhancing enzymatic activity in multi-metal systems, where zinc collaborates with other metal ions positioned in close proximity, one serving a catalytic role while others modulate activity (cocatalytic zinc) (15)