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With regards to fatty acid/lipid biosynthesis, primary hepatocytes treated with NaOX showed a significant increase in the key lipogenic genes, fatty acid synthase ( Fasn ) and acetyl-CoA carboxylase ( Acaca ), with no significant differences in the expression of stearoyl-Coenzyme A desaturase 1 ( Scd1 ) or sterol regulatory element binding transcription factor 1 ( Srebf1 ), the master regulator of fatty acid/lipid biosynthesis 45 (Extended Data Fig

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Characterization of an autoregulated response element in the mouse retinoic acid receptor type beta gene

A quick look at the chart indicates a huge separation between the ME/CFS patients (in red) and the healthy controls (in blue)

doi: 10.1016/j.bcp.2022.115103 50 SrisongkramTBahramiKJrvinenJTimonenJRautioJWeerapreeyakulN