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In this study, a significant decrease in cell viability after XPF knockdown, which also reduces ERCC1 levels, was observed in the most resistant tumor cell line, confirming that DNA repair has a fundamental role in cisplatin resistance and variation in the protein levels of XPF and ERCC1 can explain, at least partially, the acquired resistance in tumors when compared to a normal fibroblast

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Protein thiols are also significant targets of reactive oxygen species in vivo

Among the various natural products, ubiquitous hydroxylated flavonoids have been documented as a potent inhibitor of tyrosinase due to their structural similarities with tyrosinase substrates, such as l-tyrosine and l-DOPA, and substantial antioxidant properties 11,29,30,31

Although the mechanisms remain uncertain, it is hypothesized that the term HPA axis is more susceptible to glucocorticoid-mediated downregulation of central GR expression, leading to impaired negative feedback regulation