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demonstrated that matrix metalloproteinase (MMP)-9 is particularly motivated in premetastatic lung endothelial cells and macrophages mediated by primary tumors via the VEGFR-1/Flt-1 pathway, which is important for lung metastasis (94)

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Neuen BL, Oshima M, Agarwal R, Arnott C, Cherney DZ, Edwards R, et al

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