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In conclusion, lactate secreted by tumor cells acts on GPR81 of tumor cells or nontumor cells in the TME, ultimately affecting tumor cell function as well as information exchange and interactions between cells, all of which has the potential to affect tumor cell growth and proliferation

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Notable levels include lysine, threonine, and methionine (Akin Idowu et al., 2013

Nevertheless, individualized pharmacotherapy should be applied when prescribing HT, which includes baseline CVD risk assessment [13]

Ruggles, Amino Acids 41 , 73 (2011) E