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Furthermore, in vivo experiments showed that BMSCs and TSG-6 restored the MRI T2-weighted signal intensity and increased collagen II and aggrecan expression in the degenerated NP tissues

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Common mechanisms include enhancing antioxidant defenses (typically through activation of the Nrf2/ARE pathway), inhibiting pro-inflammatory signaling (e.g., NF-B and MAPK pathways), increasing nitric oxide (NO) bioavailability in endothelial cells, regulating lipid metabolism, and alleviating pathological fibrosis

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Clinical studies indicate optimal efficacy between 1-3% concentration