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10.1016/j.jsbmb.2017.01.021 142 PonziniE.ScottiL.GrandoriR.TavazziS.ZambonA

Importantly, the bicarbonate/carbonate concentrations have been identified as the main contributors to total alkalinity

Additional stability testing at room temperature and under accelerated conditions, along with formal pharmacokinetic profiling in biological media, is recommended

In addition, studies have shown that nanotechnology-based delivery systems are more effective in small animal tumor models than in human tumors, 543,592 and organoids can be attempted for evaluation