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Systemic regulation of iron metabolism primarily occurs in the liver, where hepcidin binds to FPN, leading to its degradation and inhibition of iron export, thereby contributing to intracellular iron accumulation [99]

Recent observations highlighted the critical association with intestinal flora, as confirmed by the finding that metformin decreased the relative abundance of Bacteroides fragilis while increasing Akkermansia muciniphila and Bifidobacterium bifidum

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L-ergothioneine Level in Red Blood Cells of Healthy Human Males in the Western Province of Saudi Arabia

pmid:24120123