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10.1038/nature15521 15 Casgevy and Lyfgenia (2024)

Activated by both mTORC1 and mTORC2, SGK-1 has been considered to be a negative regulator of autophagy [50, 51]

392 These findings suggest that both the proinflammatory cGASSTINGIFN axis and the anti-inflammatory cytokine IL-10 play crucial roles in mTOR-mediated mitochondrial inflammation and highlight mTOR inhibition as a potential therapeutic strategy for treating inflammatory diseases

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