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Es ideal para personas con digestin normal que pueden tomar dosis elevadas (500-1000 mg) sin molestias

Other antibiotics such as cycloserine and penicillamine have similar vitamin B-antagonizing effects, necessitating supplementation to avert neurological side effects

Most drugs in this group are available without a doctor's prescription, which increases the risk of NSAID addiction

More recent studies have suggested that the effectiveness of parenteral and high-dose oral B12 (1 mg/d) is similar in correcting serum concentrations of vitamin B12, though the evidence is of low quality

WADA has determined that these routes of administration result in a significant level of glucocorticoids circulating in the blood, which has the potential to result in performance enhancement or cause harm to health