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Tremors, bradykinesia, and postural instability manifest following a 7080% depletion of dopaminergic neurons in the substantia nigra (SN) [3] and subsequently, dopamine release in the striatum is impaired [4]

doi: 10.1016/j.jtemb.2021.126801 39 TurnerRJWeinerJHTaylorDE

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This is the first report of the development of testicular atrophy of the testes in patients with chronic alcoholism and APAP-induced LC