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In the present investigation, extreme accumulation of H 2 O 2 at MDS and SDS in the sensitive variety might be due to acceleration of the Haber-Weiss reaction that causing formation of hydroxyl radical (OH), hence, resulting in more MDA production and damage of cell membrane 8

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7.1.1.1 Monoclonal antibodies Antibodies targeting specific cytokines, such as TNF- inhibitors (e.g., infliximab and adalimumab), have been shown to decrease the levels of systemic inflammation and reduce BBB dysfunction (Esposito and Cuzzocrea, 2009)

Ensuring safety during therapy requires real-time temperature monitoring and precise control of MF parameters (Shoshiashvili et al., 2023)

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Together, these steps outline a feasible bench-to-bedside strategy, addressing both regulatory and translational gaps