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The significance of this paper is not only to compare the three routes of administration but also to evaluate them and determine which route is the best to administrate the drug

The prevalence of pruritus varies depending on the underlying cause, with reports indicating rates of up to 70% in primary biliary cholangitis, 2.530% in chronic hepatitis C virus-related liver disease, and roughly 8% in cirrhosis attributed to hepatitis B virus infection ( Numerous hypotheses have been posited to elucidate the genesis of pruritus, albeit none deemed definitive

A neuropsychological test battery, as well as clinical and self-report scales along with general and social functioning were used to assess the degree of depression

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& Tatli, B