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Alternative methods, such as combining pantoprazole with docetaxel in metastatic castration-resistant prostate cancer, showed that although safe, not every autophagy-targeting strategy achieves the established efficacy benchmarks, highlighting the importance of accurate patient stratification

Furthermore, the aging ECM, enriched with degradation products and inflammatory factors, combined with oxidative stress, compromises nitric oxide (NO) bioavailability, impairing NO-mediated vasodilation and blood nutrient supply 134