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If you arent responding to methotrexate after a two-month period, your rheumatologist may try some kind of combination therapy, such as adding sulfasalazine and hydroxychloroquine (called triple therapy) or adding a biologic drug such as etanercept (Enbrel), adalimumab (Humira), or infliximab (Remicade)

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These lifestyle changes include: avoiding smoking, if applicable getting regular exercise maintaining a healthful weight finding ways to manage stress getting enough sleep Vitamin B12 is a water-soluble vitamin