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We show that estrogen 4-hydroxylation is the main metabolic pathway of endogenous estrogens catalyzed by brain microsomes which contain all cellular cytochrome P450 enzymes, suggesting that 4-hydroxyestrogens are the main estrogen metabolites formed in the CNS

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Abstract Melasma is a chronic hyperpigmentation skin disorder that is more common in the female gender

These injections can help regulate insulin and glucose metabolism, which is essential for maintaining a healthy weight [5]

This review summarizes recent findings on the interplay between estrogen signaling, autophagy, and ferroptosis, highlighting their potential impact on human health