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Likewise, it is not known which of these pathophysiological effects of apoE4 is the primary effect and which are subsequent or downstream effects or the extent to which they contribute to the pathogenesis of the dementia that characterizes AD clinically

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The second mutation, which, in combination with p.C282Y, is responsible for another 5% of HC cases is p.H63D (substitution of histidine instead of aspartame)

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