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Tetrahydronaphthyridinols (THN) constitute a specific group of aza-phenols, which are considered the most promising synthetic compounds to inhibit ferroptosis (Reference Valgimigli and Pratt61)

Koundouros, N

Sohal RS, Forster MJ (2014) Caloric restriction and the aging process: a critique

Typical examples are flavonoids which are due to the number of hydroxyl groups very good in vitro antioxidants, however, under in vivo environment they undergo structural changes and transformations and therefore their antioxidant capacity is significantly reduced

However, there is evidence that similar mechanisms operate in presbycusis