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In vitro experiments typically employed micromolar concentrations of mitragynine or kratom extracts, which are appropriate for interrogating receptor binding, ion channel modulation, and intracellular signaling but likely exceed circulating concentrations reported in human users [21, 23, 29, 30]

I feel fuller for longer, and those intense cravings I used to get are much more manageable, which is a huge win for maintaining my calorie deficit

This can lead to sensory overload or discomfort in noisy or bright environments