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[42] reported that the DNA-TG/MP dose ratio was significantly higher for patients carrying NUDT15 variants compared with patients with wild-type NUDT15 ( P A variants demonstrated a significantly higher DNA-TG to MP dose ratio ( P = 0.031, n = 16) and a higher DNA-TG to MP dose ratio was associated with higher risk of developing leukopenia ( P = 0.025) [43]

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