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Furthermore, HIF-1 activation is closely associated with tumor migration and invasion, as it can upregulate matrix metalloproteinases (MMPs) and other proteins, facilitating extracellular matrix degradation and increasing tumor cells' invasive and metastatic potential (52)

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Zinc deficiency, however, also lowers T3 [8] and may occur over time with the consumption of certain food chemicals such as high fructose corn syrup [9], tartrazine and sunset yellow [10, 11]