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doi: 10.1016/j.semcancer.2014.01.002

Because spermidine is not only obtained from the diet but is also endogenously synthesised and produced by the gut microbiota, the total polyamine pool reflects the combined contribution of all three sources, making it difficult to detect a shortage from any single source, and therefore true dietary depletion conditions are unlikely to occur 9

Such cross-cutting impacts highlight the systemic role of WRRFs in advancing multiple development targets simultaneously

Antioxidant enzyme support: Research demonstrates the compound increases superoxide dismutase (SOD), catalase, and glutathione peroxidase activity, reducing oxidative DNA damage and lipid peroxidation markers in aged animal models

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