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It activates key mitophagy regulators, including PTEN-induced kinase 1 (PINK1) and the E3 ubiquitin ligase Parkin, which coordinate the ubiquitination and lysosomal targeting of dysfunctional mitochondria [112]

An overlap of 78 target genes was considered as EPS-PD common targets, which was shown in a Venn diagram (Fig

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