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48 Thus, enpatoran is poised to become a promising oral therapeutic candidate for CLE, particularly for patients with moderate-to-severe skin disease who are unresponsive to current therapies

Wu et al., 2010) ( Table 2 )

However, because these genes have many other functional roles in the cell, their silencing resulted in drastic phenotypic changes in nymphs and adults and in high mortality, and this silencing signal was heritable