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Mesenchymal stromal cell therapies: Immunomodulatory properties and clinical progress

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The constant interaction between oxidants and antioxidant function is part of the normal function of cells and can lead to differences in glutathione concentrations within cellular and tissue compartments [39]

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A variety of markers have been used to identify cellular senescence, among which the senescence-associated -galactosidase (SA--gal) activity at pH 6.0, cyclin-dependent kinase (CDK) inhibitors such as p16 ink4a (hereafter referred as p16) and p21 CIP1 (hereafter referred as p21), and SASPs are the most common ones (Figure 1)

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