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FOXO4-DRI was apparently linked to lower levels of senescence markers (p53, p21, p16) and lower levels of several Senescence-Associated Secretory Phenotype factors in such cell cultures, especially IL-1, IL-6, and TGF-

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Why Hands and Feet Darken Faster Than the Face Before choosing a hand and foot whitening cream , it is essential to understand why these areas are so prone to hyperpigmentation: Thicker Skin: The skin on our palms and soles is thick, but the skin on the back of our hands and the tops of our feet is thin and lacks oil glands, making it prone to dryness and wrinkling