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Although several drug molecules have shown hepatoprotective effects in experimental conditions, their clinical use remains inconclusive until validated in well-designed clinical trials

hippocampal CA3 synapse loss, suppressed neurogenesis and chronic-stress BDNF reduction

NO is synthesized by at least three isoforms of NO synthase (NOS): - in the endothelium by endothelial NOS (eNOS), - in nerve cells mainly by neuronal NOS, - in macrophages by inducible NOS

Reduced physical activity is a common feature of ME/CFS, FM, and GWS

In the nucleus, p65 coordinates gene transcription by recruiting coactivators (e.g., CREB-binding proteins (CBP)) or corepressors (e.g., histone deacetylases (HDACs)) (Liu et al., 2008) (Figure 2B)

In the Wnt/PCP signaling pathway, Wnts bind to FZD receptors on the cell surface and further activate Jun N-terminal kinases (JNKs) by recruiting Dvl to activate the RAC and its downstream mitogen-activating protein 3 kinases (MAP3Ks) and mitogen-activated protein 2 kinases (MAP2Ks)