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Interestingly, the incubation with the antioxidant N-acetylcysteine (NAC) upon treatment with NP4 resulted in reduced levels of apoptosis, suggestive that the cytotoxicity of NP4 is related to intracellular redox homeostasis (Supplementary Fig

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The authors concluded that "those with ASDs are affected by an imbalance between their anti-oxidative and oxidative stress systems, a condition which could be treated with glutathione supplementation"

Sochman, J., N-Acetylcysteine Somewhere Between Scylla and Charybdis

Molecular characterization, regulation, heterologous expression, and enzyme properties

Glutaminolysis as a target for cancer therapy