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Tobacco Smoking also depletes glutathione levels, contributing to inflammation and decreased lung function

Unlike endogenous cannabinoids, THC also increases mitochondrial hydrogen peroxide production [39], and reactive oxygen species (ROS) production and neuronal apoptosis in mPFC [32], a brain region critically involved in neuropsychiatric pathology

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However, further investigation requires further investigation of the underlying biochemical and molecular processes by which melatonin exerts its neuroprotective effects in cerebral I/R injury

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