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In a head-to-head open-label trial reported in February 2026, average weight loss at 84 weeks favored tirzepatide, and the sponsor noted CagriSema did not meet its prespecified non-inferiority target against tirzepatide

Arteriosclerosis, thrombosis, and vascular biology, 2021

Intraindividual normalization of the main agalactosylated glycan (FA2) of IgG1 vs FA2-IgG2 was used to distinguish IIM-ILD from IIM-nonILD, which showed that the area under the curve (AUC) of this standard was 88 6%