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A Phase 2 study published in The New England Journal of Medicine (Jastreboff et al., 2023) reported substantial weight reduction in participants with obesity

And compared to some classic actives, peptides are often easier to tolerate (especially if skin gets cranky with strong exfoliants or retinoids)

M., Seidman, E

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[6] After parenteral delivery, cyanocobalamin binds transcobalamin II, permitting receptor mediated endocytosis into virtually all nucleated cells

Rapid degradation of GLP-1 and GIP (DPP-IV) enzymes by dipeptidyl peptidase-IV emphasises the importance of DPP-IV inhibition