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10.14188/j.1671-8852.2012.05.003 38 WangS

This review synthesizes clinical and preclinical findings to elucidate the relationship between gut microbiota dysbiosis and aberrant inflammatory signaling in the periphery and central nervous system in schizophrenia

Topical clindamycin (Cleocin T, Clinda-Derm) and erythromycin (Akne-Mycin, ATS, Erycette, Erygel, Ilotycin) are antibiotics that are also anti-inflammatory drugs and work well against many bacteria

MOTS-c was found to upregulate key genes in the TGF-/Smad pathway (such as TGF-1, TGF-2, and Smad7) and increase the expression of bone formation markers like alkaline phosphatase (ALP), osteocalcin, and Runx2 in bone cells

Start with lower doses of each when combining

It also discusses key challenges in their development and explores future directions, including clinical considerations and emerging research with triple agonists