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Membranes were blocked with Odyssey blocking buffer (LICOR, Omaha, NE, USA) and incubated overnight with an antibody against hypoxia inducible factor-1 (HIF-1, Cell Signaling Technology # 36169

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The most widely recognized polyphenols classes are flavonoids, phenolic acids, stilbenes (including resveratrol), tannins, coumarins, curcuminoids and lignans