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In an umbrella review by Niloufar Rasaei et al., which took into account 97 meta-analyses on the influence of pre-, pro-, and synbiotics on anthropometric parameters such as BMI, body weight, and waist circumference in obese individuals, the authors showed a positive impact of these therapeutic methods in the general population

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Experimental data suggests its efficacy and capability to cure PC, but rising concern for the safety and associated adverse effects of nanoformulations has presented another setback for curcumin clinical use

However, levels may be depleted by kidney disease, liver disease, genetic defects, valproic acid (an epilepsy drug), cancerand advancing age

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