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For the non-interventional cohort, a group size of 20 subjects will detect a minimum difference in baseline GSH of at least 16% between young and elderly healthy subjects (0.05 alpha, 0.8 power) based on an inter-subject CV of 22%

In two multicenter studies of over 1,500 patients requiring NSAID therapy, HZT-501 demonstrated a ~55% reduction in the risk of ulcer (determined by endoscopy) compared to ibuprofen alone over 24 weeks (Laine 2012)

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We avoid exosomes in routine practice now unless there is a tightly justified, risktolerant scenario and clear oversight

Fewer have a plan that is specific enough to follow

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