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Name: l-carnitine chemotherapy neuropathy Frontiers Acetyl-l-Carnitine in the Treatment of
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Neuropathic ENS degeneration of autoimmune origin includes loss of inhibitory musculomotor neurons and is a progressive disease that in its early stages may manifest as symptoms that might be interpreted as irritable bowel syndrome (IBS)

There are two patterns of NBD after SCI: upper motor neuron bowel dysfunction, which results from an SCI above the sacral level, and lower motor neuron bowel dysfunction, arising as a result of a lesion to the sacral spinal cord, roots, or peripheral nerve innervation of the colon [214]

Many consistent alterations in the microbiome lead toward a causative or contributory role, and early interventions of microbiota could influence the progression of the disease and the severity of its symptoms