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79 LiS.YangL.ZhangY.ZhangC.ShaoJ.LiuX.et al (2017)

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Ochratoxin A mediates MAPK activation, modulates IL-2 and TNF-alpha mRNA expression and induces apoptosis by mitochondria-dependent and mitochondria-independent pathways in human H9 T cells

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A depressive phenotype was observed in the GS and GLT-1 cKO mice, correlated with increased levels of reactive oxygen/nitrogen species (ROS/RNS) within the mPFC, whereas a reduction in Glu-Gln concentrations was uniquely identified in the GS cKO mice

Therapeutic applications Given the dependence of cancer cells on glutamine metabolism, targeted therapies have been developed against glutamine metabolism, from glutamine uptake to glutamine-catalysed enzymes