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A theoretical model of gamma-globulin catabolism

Nanomaterials 10 (2), 376

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Mitochondrial dysfunction prevents repolarization of inflammatory macrophages

Up to now, powerful genetic tools allowed clarification of the significance, dispensability and potential of cystine transporters for ferroptotic cell death in PDAC and breast cancer ( via xCT ( A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport ( in vitro studies as efficient inducer of ferroptosis in many different cancer types, including breast, PDAC, lymphoma, renal, brain and ovarian cancers (50, 51) and sorafenib (52)

Patients who developed fibrosis (n=434