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These appear to be dose-dependent and typically resolve with dose reduction

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Leptin controls adipose tissue lipogenesis via central, STAT3-independent mechanisms

Uncoupling protein (UCP)-1 has been shown to be activated in HIV-associated lipodystrophy and in agreement, calcyphosine-like (CAPSL), important in early adipogenesis, was down-regulated and uncoupling protein (UCP)-1 upregulated in eleven individuals, one with familial MSL and ten with sporadic MSL disease (276)