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Activation or inhibition activities were measured as described ( Reduction of the Intracellular ROS Level in HEK293T Cells HEK293T cells were cultured in Dulbeccos modified Eagles medium (DMEM

Finally, even if virtually all glutamate is oxidized in astrocytes, pyruvate formed from malate could be converted to lactate and transferred to neurons, but most evidence does not support lactate transfer from astrocytes to neurons

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Benfotiamine administration has been shown to increase the levels of intracellular thiamine and reduces AGEs that induce experimental diabetic neuropathy 179,180