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Cyclic voltammetry shows that the Cys-FeS clusters are redox-active, albeit their reduction potentials are higher than most modern ferredoxins, and closer to the range of high-potential ironsulfur proteins 30

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By recognising aberrant intracellular DNA, it activates innate immunity and bridges to adaptive immunity, thereby enhancing antigen immunogenicity ( + T-cell responses ( Figure 1 ), and providing an outlook on current challenges and future development directions