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Food and Chemical Toxicology 45(12):24412445 Tchekalarova J, Kubov H, Mare P (2007) Effects of postnatal caffeine exposure on seizure susceptibility in developing rats

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Oxidative stress and antioxidant studies

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[89] collected urine samples over a 24-hr period and found at rest there was no significant change in urine output at rest when consuming water or varying doses of caffeine in the range of 114 mg/d-253 mg/d (1.4 mg/kg - 3.13 mg/kg)

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Reported side effects include water retention, flushing, headache, tingling in the extremities, elevated IGF-1 levels, impaired glucose tolerance, and injection site reactions including pain and infection risk

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Chem Sci 5:29252932

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National Institutes of Health, 2015)

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