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Smad3 is a common signaling protein that can directly promote the expression of pro-fibrotic genes as a transcription factor

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Indeed, neutrophil activation and degranulation, including extrusion of NETs via NETosis, are all PPP- and ROS-dependent processes, generated by NOX activity ( In particular, neutrophil NETosis is a critical neutrophil effector function, which releases chromatin and granule proteins into the extracellular space to entangle and kill bacteria ( Figure 1A-2 )