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S., Fraser, E

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In the present study, we explored VEGF-independent angiogenic factors in NSCLC and demonstrated that hepatoma-derived growth factor (HDGF) enhances VEGF-dependent angiogenesis and that fibroblast growth factor-2 (FGF-2) is a VEGF-independent angiogenic factor in human NSCLC cells

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In later stages (lower panel), intact T cells are observed breaching the plasma membrane of myofibroblast-like cells and penetrating the cytoplasm toward the nuclear lamina (red arrow), accompanied by pronounced organelle damage