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Interestingly, the metabolomics results showed that the synergistic effect was related to metabolic disorders, especially the substantial influence on glycerophospholipid metabolism, which significantly increased membrane permeability

Hence, these collected results established the substantial stability of the docked flavonoids with mh-Tyr and to function as an alternative substrate in presence of a specific substrate to reduce or inhibit the catalytic activity of the mh-Tyr enzyme, as predicted from docked poses (Fig

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This extraordinary property allows R-ALA to penetrate virtually every tissue in the body, including the lipid-rich membranes of cells and the interior aqueous cytosol

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