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doi: 10.1038/s41586-020-2588-y 12 NishigaMWangDWHanYLewisDBWuJC

Oxidant variables The slower rates of glutathione synthesis in the elderly subjects at baseline were associated with significantly higher concentrations of markers of oxidative damage (plasma reactive oxygen metabolites, plasma F 2 -isoprostanes, and lipid peroxides

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Antiepileptic effects of antioxidant potent extract from Urtica dioica Linn

Targeted therapy against ROS A synthetic antioxidant regimen has been established with four main approaches: lipid-lowering, blood pressure-lowering, thiol supplementation, and enzyme replacement Statins block the mevalonate pathway by inhibiting 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, reduce Rac1 membrane translocation, thereby lowering ROS derived from NOX, while stabilizing eNOS mRNA, increasing NO bioavailability, and inhibiting various adhesion molecules, achieving a dual suppression of oxidative stress and inflammation [486]

Individual cardiovascular events (coronary artery disease/congestive heart failure, myocardial infarction, and stroke) showed no significant differences between regions along with renal impairment (table)