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miR-34c directly targets AR mRNA, inhibiting androgen receptor translation and compromising sperm maturation processes ( 3.5.1.2 Long non-coding RNA alterations NEAT1 undergoes upregulation following BPA exposure, influencing spermatogonial stem cell fate determination through miR-148a-3p sponging mechanisms ( 3.5.2 Protein modifications and chromatin remodeling 3.5.2.1 Post-translational modifications EED exposure promotes androgen receptor protein ubiquitination, accelerating AR degradation and reducing transcriptional activity (60)

A reduction in microbiome diversity has been identified (191), but it is likely that the microbiome composition will differ between ME/CFS patients as each patient has a unique infectious history (193)

for model calibration and validation this manuscript used GSH and GSSG data collected as part of a previously published study (Gimeno-Hernndez et al

NaHC03, CH 2 CI 2 (b) Nal/acetone (if required), (c) CI-CH 2 -OCOCI, base, S Reagents: (a) Cat

doi:10.1038/ejcn.2017.132 Smeyne M, Smeyne RJ