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In addition, the mRNA for the ECM remodeling enzyme MMP2 was significantly upregulated in the DM_CKD group compared to DM alone and with a trend towards upregulation vs WT, with no significant changes observed in MMP9 but a trend towards increased TIMP1 expression in DM_CKD vs WT as well as DM

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The presence of ROS stimulates the production of GSH by increasing cystine uptake and promoting the expression of GCL 34

Hegazy AK, Abdel-Ghani NT, El-Chaghaby GA (2011) Phytoremediation of industrial wastewater potentiality by Typha domingensis

D.BoettgerT.SinghN.GanapathyV

[2] [3] In pivotal clinical trials such as SUSTAIN for diabetes and STEP for obesity, semaglutide has achieved mean HbA1c reductions of 1.5-2.0% and body weight losses of 14.9-17.4% over 68 weeks in non-diabetic overweight or obese individuals, outperforming placebo and comparators like liraglutide through multifaceted effects on energy balance and incretin pathways