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To restore drug sensitivity and further enhance antitumor effects, the hybrid siRNA anti-Survivin and anti-MDR1 (siSM) were treated as a model therapeutics via a PGS delivery system, resulting in a knockdown of Survivin and MDR1 and further sensitizing cancer cells to the drug cisplatin (DDP), PGS complexes were injected intravenously into a lung in situ tumor model, and it was found that PGS/siSM relatively reduced the growth rate of tumors, while simultaneous administration of PGS/siSM and DDP enhanced this effect ( in vivo and in vitro , down-regulating intratumoral induction of CD47 gene, mRNA and protein functioning as evading phagocytic clearance through binding to the immune receptor SIRP

Tryptophan consumption and indoleamines production by peritoneal cavity macrophages

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Endophytic selenobacteria and arbuscular mycorrhizal fungus for selenium biofortification and Gaeumannomyces graminis biocontrol

O.MenteseA.DemirS.KerimogluG.ColakF.BodurA.et al (2020)

Miyake, K., Ohmori, K., Ishii, A